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  1. Home
  2. Tools & Technologies
  3. Model creation - Personalized genome engineering
  4. Knock-in
Mouse, Rat or Cell?
CRISPR/Cas9 Genome Editing
Homologous Recombination in ES cells
Genotyping
Knock-out
Knock-in
Rosa26 Targeting Overexpression
Humanization
Structural variants
Flex models
Pronuclear Injection
In vivo Viral Transduction
Flp and Cre Deleters
Our recommendations

Knock-in (KI) models are used to introduce either a mutation in a specific gene or an additional DNA sequence.

 

Advantages

  • Multiple applications: human disease recapitulation, compound efficacy assessment, promoter activity study, mutant protein expression, cell trafficking following by marker gene introduction, gene replacement by reporter gene, humanization.

Drawbacks

  • Modification of human orthologue proteins in mouse may not completely reflects the role of a gene in human pathology.

Recommended technics

Depending on your project and objectives, KI animals can be obtained through

For KI models generation request please contact us

PHENOMIN expertise

  • Personalized genome engineering service to fit our customer needs.
  • Implication in international consortia (near 20 different consortia) to benefit from the last technics and scientific expertise.
  • Continuous R&D activity to improve our technics and success rate and propose our customers the best approach for their projects.