Humanization

Humanization models are specific models in which a human sequence or material has been introduced (gene replacement, point mutation, BAC transgene injection or even graft models).

These models are used to mimic a human pathology or to evaluate a drug effect on human proteins; they are often used to study cancer, inflammatory and infectious diseases and hematopoiesis.

Advantages

• The human protein is expressed under physiological conditions, using mouse promoter and regulatory regions

Drawbacks

• Model design is complex to preserve physiological expression and regulation of the human gene inserted into the mouse genome

PHENOMIN expertise

• Personalized genome engineering service to fit our customer needs
• Implication in international consortia (near 20 different consortia) to benefit from the last technics and scientific expertise
• Continuous R&D activity to improve our technics and success rate and propose our customers the best approach for their projects

For any humanization request please contact us